2,2,2-TRIFLUORO-1-(4-CHLORO-PHENYL)-ETHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 2,2,2-TRIFLUORO-1-(4-CHLORO-PHENYL)-ETHYLAMINE HYDROCHLORIDE
• CAS No.: 65990-86-5
• Molecular Formula: C8H7ClF3N.ClH
• Molecular Weight: 246.059
• Hs Code.: 2921499090
• Mol file: 65990-86-5.mol

Synonyms:Benzenemethanamine,4-chloro-a-(trifluoromethyl)-,hydrochloride (9CI);2,2,2-Trifluoro-1-(4-chlorophenyl)ethylamine hydrochloride;1-(4-Chlorophenyl)-2,2,2-trifluoroethanamine hydrochloride (1:1);1-(4-chlorophenyl)-2,2,2-trifluoro-ethanamine hydrochloride;

Chemical Property of 2,2,2-TRIFLUORO-1-(4-CHLORO-PHENYL)-ETHYLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 26.02000
• LogP: 4.40440

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Chlorophenyl)-2,2,2-trifluoroethan-1-amine hydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-TRIFLUORO-1-(4-CHLORO-PHENYL)-ETHYLAMINE HYDROCHLORIDE

There total 2 articles about 2,2,2-TRIFLUORO-1-(4-CHLORO-PHENYL)-ETHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

benzylidene-1-(4-chlorophenyl)-2,2,2-trifluoroethylamine (1356140-79-8) → C8H7ClF3N*ClH (65990-86-5)

Guidance literature:

With hydrogenchloride; water; In diethyl ether; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2011.11.088

Reference yield:

4'-chloro-2,2,2-trifluoroacetophenone (321-37-9) → C8H7ClF3N*ClH (65990-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Nafion-H SAC-13 / toluene / 24 h / 185 °C

2: hydrogenchloride; water / diethyl ether / 24 h / 20 °C

With hydrogenchloride; water; In diethyl ether; toluene;

DOI:10.1016/j.tetlet.2011.11.088

upstream raw materials:

benzylidene-1-(4-chlorophenyl)-2,2,2-trifluoroethylamine

4'-chloro-2,2,2-trifluoroacetophenone