2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide

Base Information

• Chemical Name: 2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide
• CAS No.: 170959-68-9
• Molecular Formula: C₂₁H₂₂N₂O₂
• Molecular Weight: 334.418
• Mol file: 170959-68-9.mol

Synonyms:

Chemical Property of 2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide

There total 1 articles about 2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-8-methoxyquinoline (10522-47-1) + 2-pivaloylaminophenyl boronic acid (146140-95-6) → 2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide (170959-68-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; Yield given. Multistep reaction; 1.) EtOH, toluene, 30 min. 2.) EtOH, toluene, reflux, 3 d;

DOI:10.1002/jhet.5570320428

Reference yield: 72.0%

2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide (170959-68-9) → 5-(2-aminophenyl)-8-methoxyquinoline (170959-74-7)

Guidance literature:

With sulfuric acid; for 6h; Heating;

DOI:10.1002/jhet.5570320428

Reference yield:

2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide (170959-68-9) → 5-(2-azidophenyl)-8-methoxyquinoline (170959-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / 20percent H₂SO₄ / 6 h / Heating

2: 1.) aq. H₂SO₄, NaNO₂, 2.) aq. NaN₃

With sodium azide; sulfuric acid; sodium nitrite;

DOI:10.1002/jhet.5570320428

upstream raw materials:

5-bromo-8-methoxyquinoline

2-pivaloylaminophenyl boronic acid

Downstream raw materials:

5-(2-aminophenyl)-8-methoxyquinoline

5-(2-azidophenyl)-8-methoxyquinoline