1-Boc-7-benzyloxy-3-formylindole

Base Information

• Chemical Name: 1-Boc-7-benzyloxy-3-formylindole
• CAS No.: 914348-99-5
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.402
• Hs Code.: 2933990090
• Mol file: 914348-99-5.mol

Synonyms:1-Boc-7-Benzyloxy-3-formylindole;OR1682;tert-butyl 7-(benzyloxy)-3-formyl-1H-indole-1-carboxylate;

Chemical Property of 1-Boc-7-benzyloxy-3-formylindole

Chemical Property:

• Vapor Pressure: 1.38E-10mmHg at 25°C
• Boiling Point: 511.7oC at 760 mmHg
• Flash Point: 263.3oC
• PSA: 57.53000
• Density: 1.14g/cm3
• LogP: 4.81600

Purity/Quality:

97% ^*data from raw suppliers

7-Benzyloxy-3-formylindole-1-carboxylic acid tert-butyl ester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-7-benzyloxy-3-formylindole

There total 1 articles about 1-Boc-7-benzyloxy-3-formylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(benzyloxy)-1H-indole-3-carbaldehyde (92855-65-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 7-(benzyloxy)-3-formyl-1H-indole-1-carboxylate (914348-99-5)

Guidance literature:

With dmap; In dichloromethane; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00706

Reference yield:

α-bromomethyl-γ-butene lactone (58588-90-2) + tert-butyl 7-(benzyloxy)-3-formyl-1H-indole-1-carboxylate (914348-99-5) → tert-butyl 6-(benzyloxy)-3-(hydroxy(4-methylene-5-oxotetrahydrofuran-3-yl)methyl)-1H-indole- + tert-butyl 6-(benzyloxy)-3-(hydroxy(4-methylene-5-oxotetrahydrofuran-3-yl)methyl)-1H-indole-

Guidance literature:

With ammonium chloride; zinc; In water; N,N-dimethyl-formamide; at 20 ℃; for 15h; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/ol200711f

Reference yield:

tert-butyl 7-(benzyloxy)-3-formyl-1H-indole-1-carboxylate (914348-99-5) + 3-((tert-butyldimethylsilyl)oxy)-3-(3,4,5-trimethoxyphenyl)propane-1,2-diamine → C39H51N3O7Si

Guidance literature:

tert-butyl 7-(benzyloxy)-3-formyl-1H-indole-1-carboxylate; 3-((tert-butyldimethylsilyl)oxy)-3-(3,4,5-trimethoxyphenyl)propane-1,2-diamine; In dichloromethane; for 1h; Inert atmosphere;

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00706

upstream raw materials:

7-(benzyloxy)-1H-indole-3-carbaldehyde

di-tert-butyl dicarbonate

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