1-Boc-7-methyl-3-formylindole

Base Information

• Chemical Name: 1-Boc-7-methyl-3-formylindole
• CAS No.: 914348-96-2
• Molecular Formula: C15H17 N O3
• Molecular Weight: 259.305
• Hs Code.: 2933990090
• Mol file: 914348-96-2.mol

Synonyms:OR1667;1-Boc-7-Methyl-3-formylindole;tert-butyl 3-formyl-7-methyl-1H-indole-1-carboxylate;

Chemical Property of 1-Boc-7-methyl-3-formylindole

Chemical Property:

• Vapor Pressure: 1.75E-06mmHg at 25°C
• Boiling Point: 396.1oC at 760 mmHg
• Flash Point: 193.3oC
• PSA: 48.30000
• Density: 1.12g/cm3
• LogP: 3.54540

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-7-methyl-3-formylindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-7-methyl-3-formylindole

There total 1 articles about 1-Boc-7-methyl-3-formylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methyl-1H-indole-3-carbaldehyde (4771-50-0) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-formyl-7-methyl-1H-indole-1-carboxylate (914348-96-2)

Guidance literature:

With dmap; In acetonitrile; at 20 ℃;

Reference yield: 5.0%

N-benzylidene-m-anisidine (5877-59-8,287930-02-3) + tert-butyl 3-formyl-7-methyl-1H-indole-1-carboxylate (914348-96-2) → 2-((3-methoxyphenyl)amino)-1-(7-methyl-1H-indol-3-yl)-2-phenylethanone (1428969-84-9)

Guidance literature:

With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; triethylamine; In ethanol; at 60 - 160 ℃; for 16h; Sealed tube; Microwave irradiation;

Reference yield:

N-benzylidene-m-anisidine (5877-59-8,287930-02-3) + tert-butyl 3-formyl-7-methyl-1H-indole-1-carboxylate (914348-96-2) → C29H30N2O4

Guidance literature:

With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; triethylamine; In ethanol; at 70 ℃;

DOI:10.1021/acs.jmedchem.8b00913

upstream raw materials:

7-methyl-1H-indole-3-carbaldehyde

di-tert-butyl dicarbonate

Downstream raw materials:

2-((3-methoxyphenyl)amino)-1-(7-methyl-1H-indol-3-yl)-2-phenylethanone