1-Boc-5-methyl-3-formylindole

Base Information

• Chemical Name: 1-Boc-5-methyl-3-formylindole
• CAS No.: 914348-94-0
• Molecular Formula: C15H17 N O3
• Molecular Weight: 259.305
• Hs Code.: 2933990090
• Mol file: 914348-94-0.mol

Synonyms:5-METHYL-3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;5-Methylindole-3-carboxaldehyde,N-BOC protected;1-Boc-5-Methyl-3-formylindole;5-Methyl-3-formylindole,N-BOC protected;OR1663;tert-butyl 3-formyl-5-methyl-1H-indole-1-carboxylate;

Chemical Property of 1-Boc-5-methyl-3-formylindole

Chemical Property:

• Vapor Pressure: 1.75E-06mmHg at 25°C
• Boiling Point: 396.1oC at 760 mmHg
• Flash Point: 193.3oC
• PSA: 48.30000
• Density: 1.12g/cm3
• LogP: 3.54540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-5-Methyl-3-formylindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-5-methyl-3-formylindole

There total 3 articles about 1-Boc-5-methyl-3-formylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ tert-butyl 3-formyl-5-methyl-1H-indole-1-carboxylate (914348-94-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 10h;

Reference yield:

5-methylindole-3-carboxaldehyde (52562-50-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-formyl-5-methyl-1H-indole-1-carboxylate (914348-94-0)

Guidance literature:

With dmap; In acetonitrile; at 20 ℃;

Reference yield:

5-methyl-1H-indole (614-96-0) → tert-butyl 3-formyl-5-methyl-1H-indole-1-carboxylate (914348-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 20 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide; 1: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.ejmech.2016.02.025

upstream raw materials:

5-methylindole-3-carboxaldehyde

di-tert-butyl dicarbonate

5-methyl-1H-indole

Downstream raw materials:

2-((3-methoxyphenyl)amino)-1-(5-methyl-1H-indol-3-yl)-2-phenylethanone

tert-butyl 3-(hydroxymethyl)-5-methyl-1H-indole-1-carboxylate

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