α-benzenessigsaeure-methylester

Base Information

• Chemical Name: α-benzenessigsaeure-methylester
• CAS No.: 60079-78-9
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 60079-78-9.mol

Synonyms:

Chemical Property of α-benzenessigsaeure-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-benzenessigsaeure-methylester

There total 4 articles about α-benzenessigsaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-methyl-benzaldehyde (104-87-0) + benzeneacetic acid methyl ester (101-41-7) → α-benzenessigsaeure-methylester (60079-78-9,60079-79-0,137420-61-2)

Guidance literature:

benzeneacetic acid methyl ester; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

4-methyl-benzaldehyde; In dichloromethane; at -78 ℃; for 3h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol301782s

Reference yield:

4-methyl-benzaldehyde (104-87-0) + benzeneacetic acid methyl ester (101-41-7) → syn-methyl 3-hydroxy-2-phenyl-3-(p-tolyl)propanoate + α-benzenessigsaeure-methylester (60079-78-9,60079-79-0,137420-61-2)

Guidance literature:

benzeneacetic acid methyl ester; With N-ethyl-N,N-diisopropylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

4-methyl-benzaldehyde; In dichloromethane; at 20 ℃; for 3h; Overall yield = 83 %; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol301782s

Reference yield:

α-benzenessigsaeure (72150-07-3) → E-1-methyl-4-styryl-benzene (4714-21-0,130059-91-5,130059-95-9,1657-45-0,1860-17-9) + (Z)-4-methylstilbene (1657-45-0) + α-benzenessigsaeure-methylester (60079-78-9,60079-79-0,137420-61-2)

Guidance literature:

With N,N-dimethyl-formamide dimethyl acetal; In chloroform; at 22 ℃; for 20h; Yield given. Yields of byproduct given;

upstream raw materials:

α-benzenessigsaeure

N,N-dimethyl-formamide dimethyl acetal

4-methyl-benzaldehyde

benzeneacetic acid methyl ester