2,3,5-tri-O-benzyl-α-D-ribofuranosyl dibenzyl phosphate

Base Information

• Chemical Name: 2,3,5-tri-O-benzyl-α-D-ribofuranosyl dibenzyl phosphate
• CAS No.: 900151-12-4
• Molecular Formula: C₄₀H₄₁O₈P
• Molecular Weight: 680.734
• Mol file: 900151-12-4.mol

Synonyms:

Chemical Property of 2,3,5-tri-O-benzyl-α-D-ribofuranosyl dibenzyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5-tri-O-benzyl-α-D-ribofuranosyl dibenzyl phosphate

There total 2 articles about 2,3,5-tri-O-benzyl-α-D-ribofuranosyl dibenzyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosphoric acid dibenzyl ester (1623-08-1) + 2,3,5-tri-O-benzyl-β-D-ribofuranosyl trichloroacetimidate (284036-78-8) → 2,3,5-tri-O-benzyl-α-D-ribofuranosyl dibenzyl phosphate (900151-12-4) + 2,3,5-tri-O-benzyl-β-D-ribofuranosyl dibenzyl phosphate

Guidance literature:

With 4 A molecular sieve; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1139/V06-038

Reference yield:

2,3,5-tris-O-(phenylmethyl)-β-D-ribofuranose (89361-52-4) → 2,3,5-tri-O-benzyl-α-D-ribofuranosyl dibenzyl phosphate (900151-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / CH₂Cl₂ / 20 °C

2: molecular sieves 4 Angstroem / CH₂Cl₂ / 3 h / 0 - 20 °C

With 4 A molecular sieve; potassium carbonate; In dichloromethane;

DOI:10.1139/V06-038

upstream raw materials:

phosphoric acid dibenzyl ester

2,3,5-tri-O-benzyl-β-D-ribofuranosyl trichloroacetimidate

2,3,5-tris-O-(phenylmethyl)-β-D-ribofuranose