(R)-3-(m-trifluoromethylphenyl)-butan-2-one

Base Information

• Chemical Name: (R)-3-(m-trifluoromethylphenyl)-butan-2-one
• CAS No.: 1016651-70-9
• Molecular Formula: C₁₁H₁₁F₃O
• Molecular Weight: 216.203
• Mol file: 1016651-70-9.mol

Synonyms:

Chemical Property of (R)-3-(m-trifluoromethylphenyl)-butan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-3-(m-trifluoromethylphenyl)-butan-2-one

There total 3 articles about (R)-3-(m-trifluoromethylphenyl)-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-<3-(trifluoromethyl)phenyl>-2-butanone (21906-07-0) → (R)-3-(m-trifluoromethylphenyl)-butan-2-one (1016651-70-9) + (S)-O-acetyl-1-(3'-(trifluoromethyl)phenyl)ethanol

Guidance literature:

With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; phenylacetone monooxygenase; NADPH; In methanol; at 20 ℃; for 1h; pH=8; optical yield given as %ee; enantioselective reaction; aq. buffer; Ionic liquid;

DOI:10.1039/c0gc00560f

Reference yield:

3-<3-(trifluoromethyl)phenyl>-2-butanone (21906-07-0) → (S)-3-(m-trifluoromethylphenyl)-butan-2-one + (R)-3-(m-trifluoromethylphenyl)-butan-2-one (1016651-70-9) + (R)-O-acetyl-1-(3'-(trifluoromethyl)phenyl)ethanol (172424-26-9) + (S)-O-acetyl-1-(3'-(trifluoromethyl)phenyl)ethanol

Guidance literature:

With α-D-glucose 6-phosphate; HCl buffer; 2-amino-2-hydroxymethyl-1,3-propanediol; Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase; NADPH; In methanol; at 20 ℃; for 72h; pH=8.0; Title compound not separated from byproducts.;

DOI:10.1016/j.tetasy.2007.12.008

Reference yield:

3-<3-(trifluoromethyl)phenyl>-2-butanone (21906-07-0) → (S)-3-(m-trifluoromethylphenyl)-butan-2-one + (R)-3-(m-trifluoromethylphenyl)-butan-2-one (1016651-70-9) + (S)-O-acetyl-1-(3'-(trifluoromethyl)phenyl)ethanol

Guidance literature:

With D-glucose 6-phosphate; Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase; Pseudomonas fluorescens ACB recombinant 4-hydroxyacetophenone monooxygenase; NADPH; In water; dimethyl sulfoxide; at 20 ℃; for 1h; pH=8.0; Concentration; Reagent/catalyst; Time; optical yield given as %ee; enantioselective reaction; Kinetics; aq. Tris-HCl buffer; Enzymatic reaction;

DOI:10.1016/j.tetasy.2009.03.018

upstream raw materials:

3-<3-(trifluoromethyl)phenyl>-2-butanone