{4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 225378-70-1
• Molecular Formula: C₂₈H₄₀Cl₃N₅O₈S
• Molecular Weight: 713.079

Synonyms:

Chemical Property of {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

There total 10 articles about {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-2-<<(1-hydroxycyclohexyl)methyl>amino>acetamide (160446-31-1) + (R)-4-((S)-4-Isopropyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-ylmethyl]-butyric acid → {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester (225378-70-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 25h; Yield given;

DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

1-aminomethylcyclohexanol (4000-72-0) → {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester (225378-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / Et₃N / methanol / 1.) 25 deg C, 5 min, 2.) reflux, 30 min

2: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 h / 25 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

N-lithio-(4S)-4-isopropyl-2-oxazolidone (96021-69-1,147208-39-7) → {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester (225378-70-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 67 percent / tetrahydrofuran / 5 h / 25 °C

2: (COCl)2 / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) 25 deg C, 1.5 h, 3.) reflux, 30 min

3: 2.) HBr / 1.) Et₂O, 0 deg C, 45 min, 2.) AcOH, 0 deg C, 1 h

4: 55 percent / tetrahydrofuran / 25 °C

5: 4.23 g / thiourea / propan-2-ol / 0.5 h / Heating

6: 61 percent / i-Pr₂NEt, DMAP / CH₂Cl₂ / 1.) 0 deg C, 45 min, 2.) 25 deg C, 16 h

7: 59 percent / NaHMDS / tetrahydrofuran / -78 °C / 1.) 45 min, 2.) 2 h

8: TFA / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) 25 deg C, 3 h

9: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 h / 25 °C

With dmap; oxalyl dichloride; hydrogen bromide; sodium hexamethyldisilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; thiourea; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/S0968-0896(98)00265-X

upstream raw materials:

N,N-dimethyl-2-<<(1-hydroxycyclohexyl)methyl>amino>acetamide

1-aminomethylcyclohexanol

N-lithio-(4S)-4-isopropyl-2-oxazolidone

3-(3-carboxy-1-oxopropyl)-4(S)-(1-methylethyl)-2-oxazolidinone

Downstream raw materials:

(4-{(R)-2-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-3-[dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-propyl}-thiazol-2-yl)-carbamic acid 2,2,2-trichloro-ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 225378-70-1 {4-[(R)-2-{[Dimethylcarbamoylmethyl-(1-hydroxy-cyclohexylmethyl)-carbamoyl]-methyl}-3-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send