Fmoc-Phe-Leu-OBsm

Base Information

Chemical Name:Fmoc-Phe-Leu-OBsm
CAS No.:229635-92-1
Molecular Formula:C₃₉H₃₈N₂O₇S
Molecular Weight:678.806
Hs Code.:

Synonyms:

Suppliers and Price of Fmoc-Phe-Leu-OBsm

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Fmoc-Phe-Leu-OBsm

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Fmoc-Phe-Leu-OBsm

There total 4 articles about Fmoc-Phe-Leu-OBsm which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50779-55-0
benzothiophen-2-yllithium

: 229635-92-1
Fmoc-Phe-Leu-OBsm

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) NaBH₄ / 2.) MeOH

2: 75 percent / sodium perborate tetrahydrate / acetic acid / 45 - 50 °C

3: 77.3 percent / DCC / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

4: 1.) t-BuNH₂, 2.) DIEA, HATU / 1.) MeCN, room temperature, 10-15 min, 2.) DCM, DMF, 0 deg C, 30 min; room temperature, 30 min

With sodium perborate; sodium tetrahydroborate; tert-butylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; acetic acid;
DOI:10.1021/jo982140l

Reference yield:

: 17890-56-1
benzothiophene-2-methanol

: 229635-92-1
Fmoc-Phe-Leu-OBsm

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / sodium perborate tetrahydrate / acetic acid / 45 - 50 °C

2: 77.3 percent / DCC / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

3: 1.) t-BuNH₂, 2.) DIEA, HATU / 1.) MeCN, room temperature, 10-15 min, 2.) DCM, DMF, 0 deg C, 30 min; room temperature, 30 min

With sodium perborate; tert-butylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; acetic acid;
DOI:10.1021/jo982140l

Reference yield:

: 134996-50-2
1,1-dioxobenzo[b]thiophen-2-ylmethanol

: 229635-92-1
Fmoc-Phe-Leu-OBsm

Guidance literature:: Multi-step reaction with 2 steps

1: 77.3 percent / DCC / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 1.) t-BuNH₂, 2.) DIEA, HATU / 1.) MeCN, room temperature, 10-15 min, 2.) DCM, DMF, 0 deg C, 30 min; room temperature, 30 min

With tert-butylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran;
DOI:10.1021/jo982140l