2',4'-Dihydroxy-2,3',6'-trimethoxychalcone

Base Information

• Chemical Name: 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone
• CAS No.: 100079-39-8
• Molecular Formula: C18H18 O6
• Molecular Weight: 330.33200
• Hs Code.: 2914509090
• Mol file: 100079-39-8.mol

Synonyms:2-O-Glucosyl-4-hydroxyacetophenone;2',4'-dihydroxy-2,3',6'-trimethoxychalcone;Bungeiside B;

Chemical Property of 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone

Chemical Property:

• PSA: 85.22000
• LogP: 3.01970
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2',4'-Dihydroxy-2,3',6'-trimethoxychalcone ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone

There total 6 articles about 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethoxyresorcinol (20032-42-2) + o-methoxycinnamoyl chloride (118652-93-0) → 2',4'-dihydroxy-2,3',6'-trimethoxychalcone (100079-39-8)

Guidance literature:

With boron trifluoride diethyl etherate; at 40 ℃;

DOI:10.1016/j.ejmech.2017.09.046

Reference yield:

2-hydroxyresorcinol (87-66-1) → 2',4'-dihydroxy-2,3',6'-trimethoxychalcone (100079-39-8)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium iodide; potassium carbonate / acetone / 48 h / Reflux

2: acetic acid; nitric acid / 4 h / 40 °C

3: sodium dithionite / ethyl acetate; water / 20 °C

4: sodium hydroxide / ethanol / 20 °C / pH 8 - 9

5: hydrogen; palladium 10% on activated carbon / methanol / 8 h / 20 °C

6: boron trifluoride diethyl etherate / 40 °C

With sodium dithionite; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; nitric acid; potassium carbonate; acetic acid; potassium iodide; sodium hydroxide; In methanol; ethanol; water; ethyl acetate; acetone; 6: |Friedel-Crafts Acylation;

DOI:10.1016/j.ejmech.2017.09.046

Reference yield:

1,2,3-tris-benzyloxybenzene (55020-64-9) → 2',4'-dihydroxy-2,3',6'-trimethoxychalcone (100079-39-8)

Guidance literature:

Multi-step reaction with 5 steps

1: acetic acid; nitric acid / 4 h / 40 °C

2: sodium dithionite / ethyl acetate; water / 20 °C

3: sodium hydroxide / ethanol / 20 °C / pH 8 - 9

4: hydrogen; palladium 10% on activated carbon / methanol / 8 h / 20 °C

5: boron trifluoride diethyl etherate / 40 °C

With sodium dithionite; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; nitric acid; acetic acid; sodium hydroxide; In methanol; ethanol; water; ethyl acetate; 5: |Friedel-Crafts Acylation;

DOI:10.1016/j.ejmech.2017.09.046

upstream raw materials:

2,5-dimethoxyresorcinol

o-methoxycinnamoyl chloride

2-hydroxyresorcinol

1,2,3-tris-benzyloxybenzene

Downstream raw materials:

7-hydroxy-5,8,2'-trimethoxyflavone

2,2',3',4',6'-pentamethoxychalcone

Refernces