Multi-step reaction with 9 steps
1: hydrogenchloride / methanol / 4 h / 50 °C
2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
3: diisobutylaluminium hydride / dichloromethane; hexane / 0 - 20 °C
4: potassium bromide; sodium hydrogencarbonate; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.33 h / 20 °C
5: 2-methyl-but-2-ene; sodium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol / 5 h / 20 °C
6: methanol; hexane; tetrahydrofuran / 12 h / 20 °C
7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / 1,2-dichloro-ethane / 48 h / 40 °C
8: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C
9: 2-methyl-but-2-ene; sodium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol / 5 h / 20 °C
With
hydrogenchloride; dmap; sodium hypochlorite; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium bromide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;
7: |Steglich Esterification;
DOI:10.1021/acs.jnatprod.6b00392