(3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide

Base Information

Chemical Name:(3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide
CAS No.:125191-11-9
Molecular Formula:C₄₅H₅₃N₃O₄S
Molecular Weight:732
Hs Code.:

(3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide

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Chemical Property of (3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide

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Technology Process of (3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide

There total 4 articles about (3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2481-59-6
α-(1-naphthalenylmethyl)-1-naphthalenepropanoic acid

: 125191-11-9
(3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 42.9 g / SOCl₂ / Ambient temperature

2: NH₃ gas / tetrahydrofuran / Ambient temperature

3: 80 percent / acetone / 18 h / Heating

4: conc. aq. H₂SO₄ / acetic acid / Ambient temperature

5: HOBt, DCC / dimethylformamide; CH₂Cl₂ / Ambient temperature

With thionyl chloride; sulfuric acid; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00084a008

Reference yield:

: 119808-26-3
2,2-Bis(1-naphthylmethyl)acetyl chloride

: 125191-11-9
(3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: NH₃ gas / tetrahydrofuran / Ambient temperature

2: 80 percent / acetone / 18 h / Heating

3: conc. aq. H₂SO₄ / acetic acid / Ambient temperature

4: HOBt, DCC / dimethylformamide; CH₂Cl₂ / Ambient temperature

With sulfuric acid; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00084a008

Reference yield:

: 125191-26-6
bis(1-naphthylmethyl)acetamide

: 125191-11-9
(3S,4S)-3-Hydroxy-6-methyl-4-[2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-2-phenylsulfanyl-acetylamino]-heptanoic acid ((S)-2-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / acetone / 18 h / Heating

2: conc. aq. H₂SO₄ / acetic acid / Ambient temperature

3: HOBt, DCC / dimethylformamide; CH₂Cl₂ / Ambient temperature

With sulfuric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00084a008