C₂₄H₂₂ClF₅N₂O₃

Base Information

Chemical Name:C₂₄H₂₂ClF₅N₂O₃
CAS No.:1360574-65-7
Molecular Formula:C₂₄H₂₂ClF₅N₂O₃
Molecular Weight:516.895
Hs Code.:

C<sub>24</sub>H<sub>22</sub>ClF<sub>5</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₂₄H₂₂ClF₅N₂O₃

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Technology Process of C₂₄H₂₂ClF₅N₂O₃

There total 9 articles about C₂₄H₂₂ClF₅N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1360574-64-6
C₂₉H₃₀ClF₅N₂O₅

: 1360574-65-7
C₂₄H₂₂ClF₅N₂O₃

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.666667h;
DOI:10.1016/j.bmcl.2011.10.013

Reference yield:

: 476620-55-0
(2-bromo-4,5-difluorophenyl)methanol

: 1360574-65-7
C₂₄H₂₂ClF₅N₂O₃

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / ethanol; water; toluene / 14 h / 80 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: isopropylmagnesium chloride / tetrahydrofuran / 16 h / 50 °C

5: ruthenium trichloride; sodium bromate / water; acetonitrile / 8 h / 20 °C

6: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 12 h / 45 °C

7: lithium borohydride / tetrahydrofuran / 8 h / 20 °C

8: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C

With 1H-imidazole; hydrogenchloride; ruthenium trichloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium bromate; lithium borohydride; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; paraffin oil;
DOI:10.1016/j.bmcl.2011.10.013

Reference yield:

: 1266727-98-3
[(2-bromo-4,5-difluorobenzyl)oxy](tert-butyl)dimethylsilane

: 1360574-65-7
C₂₄H₂₂ClF₅N₂O₃

Guidance literature:: Multi-step reaction with 7 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / ethanol; water; toluene / 14 h / 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: isopropylmagnesium chloride / tetrahydrofuran / 16 h / 50 °C

4: ruthenium trichloride; sodium bromate / water; acetonitrile / 8 h / 20 °C

5: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 12 h / 45 °C

6: lithium borohydride / tetrahydrofuran / 8 h / 20 °C

7: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C

With hydrogenchloride; ruthenium trichloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium bromate; lithium borohydride; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; paraffin oil;
DOI:10.1016/j.bmcl.2011.10.013