Technology Process of {(Z)-1-Fluoro-2-[(2R,3R,4S,5R,6S)-6-methoxy-3,4,5-tris-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-vinyl}-phosphonic acid diethyl ester
There total 6 articles about {(Z)-1-Fluoro-2-[(2R,3R,4S,5R,6S)-6-methoxy-3,4,5-tris-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-vinyl}-phosphonic acid diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / pyridine
2: NaH / dimethylformamide
3: cc H2SO4, MeOH
4: DMSO, oxalyl chloride, Et3N / CH2Cl2
5: ClPO3Et2, LDA / tetrahydrofuran / 6 h / -78 °C
6: 1.) Bu3SnH, AIBN; 2.) I2 / 1.) toluene, reflux, 24 h; 2.) Et2O, reflux
7: 10 percent / Et3N / PdCl2(PPh3)2 / 20 h / 90 °C / sealed tube
With
pyridine; methanol; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; iodine; tri-n-butyl-tin hydride; sodium hydride; diethyl chlorophosphate; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)79286-0
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ClPO3Et2, LDA / tetrahydrofuran / 6 h / -78 °C
2: 1.) Bu3SnH, AIBN; 2.) I2 / 1.) toluene, reflux, 24 h; 2.) Et2O, reflux
3: 10 percent / Et3N / PdCl2(PPh3)2 / 20 h / 90 °C / sealed tube
With
2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; diethyl chlorophosphate; triethylamine; lithium diisopropyl amide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)79286-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: DMSO, oxalyl chloride, Et3N / CH2Cl2
2: ClPO3Et2, LDA / tetrahydrofuran / 6 h / -78 °C
3: 1.) Bu3SnH, AIBN; 2.) I2 / 1.) toluene, reflux, 24 h; 2.) Et2O, reflux
4: 10 percent / Et3N / PdCl2(PPh3)2 / 20 h / 90 °C / sealed tube
With
oxalyl dichloride; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; diethyl chlorophosphate; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)79286-0
