6-(hydroxymethyl)-2-formylnaphthalene

Base Information

Chemical Name:6-(hydroxymethyl)-2-formylnaphthalene
CAS No.:157383-08-9
Molecular Formula:C₁₂H₁₀O₂
Molecular Weight:186.21
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(hydroxymethyl)-2-formylnaphthalene

Chemical Property:

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Technology Process of 6-(hydroxymethyl)-2-formylnaphthalene

There total 1 articles about 6-(hydroxymethyl)-2-formylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 840-65-3
dimethyl 2,6-naphthalenedicarboxylate

: 5060-65-1
2,6-naphthalenedicarbaldehyde

: 7567-87-5
6-formyl-2-naphthalenecarboxylic acid methyl ester

: 55343-77-6
methyl 6-hydroxymethyl-2-naphthalenecarboxylate

: 157383-08-9
6-(hydroxymethyl)-2-formylnaphthalene

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; N-methylaniline; In tetrahydrofuran; at 5 ℃; Further Variations:; Reagents; Solvents; Temperatures; Product distribution;

Reference yield:

: 157383-08-9
6-(hydroxymethyl)-2-formylnaphthalene

: (E)-7-{6-[(2R,4R,5S)-5-((Z)-5-Carboxy-pent-2-enyl)-4-(2-hydroxy-phenyl)-[1,3]dioxan-2-yl]-naphthalen-2-yl}-7-pyridin-3-yl-hept-6-enoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / p-toluenesulfonic acid / toluene / 3 h / Heating

2: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 45 min, 2.) CH₂Cl₂, from -70 deg C to 25 deg C

3: 1.) n-BuLi / 1.) Et₂O, hexane, -70 deg C, 2.) Et₂O, hexane, THF, -70 deg C, 1 h

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -75 deg C, 45 min, 2.) CH₂Cl₂, from -70 deg C to 25 deg C

5: 1.) t-BuOK / 1.) THF, -10 deg C, 20 min, 2.) THF, 25 deg C, 3 h

6: 2 M aq. HCl / tetrahydrofuran / 0.25 h

7: p-toluenesulfonic acid / CH₂Cl₂ / 2 h / Ambient temperature

8: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

9: 1 M aq. NaOH / methanol / 3 h / 25 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; oxalyl dichloride; potassium tert-butylate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00010a005

Reference yield:

: 157383-08-9
6-(hydroxymethyl)-2-formylnaphthalene

: (E)-7-{6-[(2R,4R,5S)-5-((Z)-5-Ethoxycarbonyl-pent-2-enyl)-4-(2-hydroxy-phenyl)-[1,3]dioxan-2-yl]-naphthalen-2-yl}-7-pyridin-3-yl-hept-6-enoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / p-toluenesulfonic acid / toluene / 3 h / Heating

2: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 45 min, 2.) CH₂Cl₂, from -70 deg C to 25 deg C

3: 1.) n-BuLi / 1.) Et₂O, hexane, -70 deg C, 2.) Et₂O, hexane, THF, -70 deg C, 1 h

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -75 deg C, 45 min, 2.) CH₂Cl₂, from -70 deg C to 25 deg C

5: 1.) t-BuOK / 1.) THF, -10 deg C, 20 min, 2.) THF, 25 deg C, 3 h

6: 2 M aq. HCl / tetrahydrofuran / 0.25 h

7: p-toluenesulfonic acid / CH₂Cl₂ / 2 h / Ambient temperature

8: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; n-butyllithium; oxalyl dichloride; potassium tert-butylate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00010a005