4-CHLORO-THIENO[2,3-B]PYRIDINE

Base Information

• Chemical Name: 4-CHLORO-THIENO[2,3-B]PYRIDINE
• CAS No.: 62226-17-9
• Molecular Formula: C7H4ClNS
• Molecular Weight: 169.634
• Hs Code.: 2934999090
• Mol file: 62226-17-9.mol

Synonyms:4-Chlorthieno<2,3-b>pyridin;I09-1568;4-Chloro-thieno[2,3-b]pyridine;

Chemical Property of 4-CHLORO-THIENO[2,3-B]PYRIDINE

Chemical Property:

• Vapor Pressure: 0.0234mmHg at 25°C
• Melting Point: 29.5-30 °C(Solv: hexane (110-54-3))
• Refractive Index: 1.695
• Boiling Point: 257.5 °C at 760 mmHg
• PKA: 2.74±0.30(Predicted)
• Flash Point: 109.5 °C
• PSA: 41.13000
• Density: 1.435 g/cm³
• LogP: 2.94970

Purity/Quality:

96% purity ^*data from raw suppliers

4-Chlorothieno[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-THIENO[2,3-B]PYRIDINE

There total 6 articles about 4-CHLORO-THIENO[2,3-B]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl α-carboethoxy-β-(N-2-thienylammonium) acrylate (59713-52-9) → 4-chlorothieno<2,3-b>pyridine (62226-17-9)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenyl ether / 1.5 h / Heating

2: aq. NaOH / 0.5 h / Heating

3: 1 h / Heating

4: POCl₃ / 2 h / Heating

With sodium hydroxide; trichlorophosphate; In diphenylether;

Reference yield:

4-hydroxythieno<2,3-b>pyridine (65075-96-9) → 4-chlorothieno<2,3-b>pyridine (62226-17-9)

Guidance literature:

With trichlorophosphate; for 2h; Heating;

Reference yield:

7H-thieno[2,3-b]pyridin-4-one (110651-85-9) → 4-chlorothieno<2,3-b>pyridine (62226-17-9)

Guidance literature:

With trichlorophosphate; for 4h; Heating;

upstream raw materials:

4-hydroxythieno<2,3-b>pyridine

7H-thieno[2,3-b]pyridin-4-one

ethyl α-carboethoxy-β-(N-2-thienylammonium) acrylate

ethyl 4-hydroxythieno[2,3-b]pyridine-5-carboxylate

Downstream raw materials:

N,N-dimethyl-4-(thieno[2,3-b]pyridin-4-yl)cyclohexan-1-amine

4-Chlorthieno<2,3-b>pyridin-7-oxid