Technology Process of 1,1''-[thiophene-2,5-diylbis(hydroxymethylene)]bis[2-[(cyclohexylmethylamino)methyl]ferrocene]
There total 1 articles about 1,1''-[thiophene-2,5-diylbis(hydroxymethylene)]bis[2-[(cyclohexylmethylamino)methyl]ferrocene] which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; ammonium chloride;
In
tetrahydrofuran; hexane;
(under Ar, in dark); thiophene added to soln. of butyllithium and N,N,N',N'-tetramethylethane-1,2-diamine in hexane, refluxed for 2 h, cooled toroom temp., added dropwise to soln. of Fe-complex in THF at 0°C, warmed to room temp.; aq. NH4Cl added, aq. phase extd. with Et2O, organic phase washed with H2O, brine, dried over MgSO4, concd., SiO2 column chromy. with Et2O/hexane;
DOI:10.1002/hlca.200800461
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
boron trifluoride diethyl etherate;
In
dichloromethane;
(under Ar, in dark); ligand and Fe-complex in CH2Cl2 degassed for 20 min, 4,5-dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile added, BF3*(CH3CH2)2O added, refluxed for 1 h, cooled; concd., residue dissolved in CH2Cl2, basic Al2O3 chromy. eluted with CH2Cl2, collected, ppt. washed with acetone, recrystd. from CH2Cl2/MeOH; elem. anal.;
DOI:10.1002/hlca.200800461
