8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one

Base Information

Chemical Name:8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one
CAS No.:384836-01-5
Molecular Formula:C₃₈H₄₁FN₈O₅S
Molecular Weight:740.859
Hs Code.:

8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[<i>a</i>]naphthalen-6-one

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Chemical Property of 8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one

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Technology Process of 8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one

There total 7 articles about 8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 384835-98-7
4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide

: 384836-01-5
8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: KHMDS / tetrahydrofuran / 3 h

2: tBuOK / 2-methyl-propan-2-ol / 1 h / 80 °C

3: DIEA / propan-1-ol / 4 h / Heating

With potassium tert-butylate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; propan-1-ol; tert-butyl alcohol;
DOI:10.1016/S0960-894X(01)00466-8

Reference yield:

: 384835-97-6
4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

: 384836-01-5
8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: DCC; pentafluorophenol / dimethylformamide; ethyl acetate / 0 °C

1.2: 80 percent / NH₃ / tetrahydrofuran / 20 °C

2.1: KHMDS / tetrahydrofuran / 3 h

3.1: tBuOK / 2-methyl-propan-2-ol / 1 h / 80 °C

4.1: DIEA / propan-1-ol / 4 h / Heating

With 2,3,4,5,6-pentafluorophenol; potassium tert-butylate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; propan-1-ol; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0960-894X(01)00466-8

Reference yield:

: 384835-95-4
4,6-dichloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

: 384836-01-5
8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-5-(4-fluoro-benzylamino)-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 60 percent / NH₃ / ethanol / 168 h / 20 °C

2.1: 78 percent / aq. LiOH / tetrahydrofuran; methanol / 24 h

3.1: DCC; pentafluorophenol / dimethylformamide; ethyl acetate / 0 °C

3.2: 80 percent / NH₃ / tetrahydrofuran / 20 °C

4.1: KHMDS / tetrahydrofuran / 3 h

5.1: tBuOK / 2-methyl-propan-2-ol / 1 h / 80 °C

6.1: DIEA / propan-1-ol / 4 h / Heating

With lithium hydroxide; 2,3,4,5,6-pentafluorophenol; potassium tert-butylate; ammonia; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; propan-1-ol; ethanol; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0960-894X(01)00466-8