N-[4-[(4-Chlorophenyl)Methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetaMide

Base Information

Chemical Name:N-[4-[(4-Chlorophenyl)Methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetaMide
CAS No.:1415834-63-7
Molecular Formula:C₂₀H₁₅ClF₂N₂O₂
Molecular Weight:388.801
Hs Code.:
Mol file:1415834-63-7.mol

Synonyms:

Suppliers and Price of N-[4-[(4-Chlorophenyl)Methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[4-[(4-Chlorophenyl)methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetamide
500mg
$ 1320.00

DC Chemicals
CPDA >98%
1 g
$ 2200.00

Crysdot
CPDA 98+%
50mg
$ 561.00

Crysdot
CPDA 98+%
100mg
$ 832.00

Crysdot
CPDA 98+%
10mg
$ 153.00

Crysdot
CPDA 98+%
5mg
$ 97.00

ChemScene
CPDA 99.11%
100mg
$ 960.00

ChemScene
CPDA 99.11%
10mg
$ 170.00

ChemScene
CPDA 99.11%
50mg
$ 640.00

Ambeed
CPDA 98+%
10mg
$ 235.00

Total 29 raw suppliers

Chemical Property of N-[4-[(4-Chlorophenyl)Methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetaMide

Chemical Property:

Boiling Point:579.9±50.0 °C(Predicted)
PKA:11.97±0.70(Predicted)
Density:1.381±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

N-[4-[(4-Chlorophenyl)methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-[4-[(4-Chlorophenyl)methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetamide is identified to be a potent 5'-inositol phosphatase 2 (SHIP2) inhibitor and can enhance in vitro insulin signaling through the Akt(protein kinase B) pathway. N-[4-[(4-Chlorophenyl)methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetamide is identified to be a potent 5''-inositol phosphatase 2 (SHIP2) inhibitor and can enhance in vitro insulin signaling through the Akt(protein kinase B) pathway.

Technology Process of N-[4-[(4-Chlorophenyl)Methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetaMide

There total 4 articles about N-[4-[(4-Chlorophenyl)Methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124-33-0
4-nitraminopyridine N-oxide

: 1415834-63-7
CPDA

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 15 h / 100 °C

2.1: p-toluenesulfonyl chloride / dichloromethane / 1.67 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 48 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C / Reflux

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.01.014

Reference yield:

: 873-76-7
para-Chlorobenzyl alcohol

: 1415834-63-7
CPDA

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 15 h / 100 °C

2.1: p-toluenesulfonyl chloride / dichloromethane / 1.67 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 48 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C / Reflux

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.01.014

Reference yield:

: 1415834-85-3
t-butyl[4-(4-chlorobenzyloxy)pyridin-2-yl]amine

: 1415834-63-7
CPDA

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 48 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C / Reflux

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2013.01.014