(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

Base Information

Chemical Name:(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide
CAS No.:888034-75-1
Molecular Formula:C₃₆H₅₂N₂O₅S
Molecular Weight:624.885
Hs Code.:

(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

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Chemical Property of (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

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Technology Process of (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

There total 2 articles about (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-tetrolyloxybicyclo[2.2.1]heptane-1-methanesulfonamide

: 2904-57-6
mesitylenecarbonitrile oxide

: (+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-5-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

: 888034-75-1
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

Guidance literature:: In tetrahydrofuran; for 168h; Heating;
DOI:10.1021/jo0602569

Reference yield:

: 99295-72-4
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-hydroxybicyclo[2.2.1]heptane-1-methanesulfonamide

: 888034-75-1
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / trimethylaluminum / hexane; toluene / 72 h / Heating

2: 13 percent / tetrahydrofuran / 168 h / Heating

With trimethylaluminum; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo0602569

Reference yield:

: 888034-75-1
(+)-(1R,2S,4S)-N,N-dicyclohexyl-7,7-dimethyl-2-(5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxy)bicyclo[2.2.1]heptane-1-methanesulfonamide

: (S)-2-Phenyl-propionic acid 5-methyl-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium borohydride

2: DCC; DMAP

With dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide;
DOI:10.1021/jo0602569