Quinine

Base Information

• Chemical Name: Quinine
• CAS No.: 72402-53-0
• Deprecated CAS: 12239-42-8,128544-03-6,21480-31-9,55980-20-6,6912-57-8,72646-90-3,767303-40-2,840482-04-4,857212-53-4,864908-93-0,899813-83-3,906550-97-8,909767-48-2,909882-78-6,910878-25-0,875538-34-4,888714-03-2,890027-24-4,894767-09-0,898813-59-7,898814-28-3,900786-66-5,900789-95-9,909263-47-4,910880-97-6,911445-75-5,918778-04-8,1071756-51-8,95650-40-1,1267651-57-9,1628705-47-4,2244812-93-7,2244812-97-1,2409557-51-1,2566761-34-8,1071756-51-8,1267651-57-9,128544-03-6,1628705-47-4,21480-31-9,55980-20-6,6912-57-8,767303-40-2,840482-04-4,857212-53-4,864908-93-0,875538-34-4,888714-03-2,890027-24-4,894767-09-0,898813-59-7,898814-28-3,899813-83-3,900786-66-5,900789-95-9,906550-97-8,909263-47-4,909767-48-2,909882-78-6,910878-25-0,910880-97-6,911445-75-5,918778-04-8,95650-40-1
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• European Community (EC) Number: 205-003-2,231-437-7
• UNII: A7V27PHC7A
• DSSTox Substance ID: DTXSID0044280
• Nikkaji Number: J654.524F
• Wikipedia: Quinine
• Wikidata: Q189522,Q27166273
• NCI Thesaurus Code: C29399,C794,C75269
• RXCUI: 9071
• Pharos Ligand ID: TTP1BWG4HT3M
• Metabolomics Workbench ID: 42816
• ChEMBL ID: CHEMBL170

Synonyms:Biquinate;Bisulfate, Quinine;Hydrochloride, Quinine;Legatrim;Myoquin;Quinamm;Quinbisan;Quinbisul;Quindan;Quinimax;Quinine;Quinine Bisulfate;Quinine Hydrochloride;Quinine Lafran;Quinine Sulfate;Quinine Sulphate;Quinine-Odan;Quinoctal;Quinson;Quinsul;Strema;Sulfate, Quinine;Sulphate, Quinine;Surquina

Chemical Property of Quinine

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 324.183778013
• Heavy Atom Count: 24
• Complexity: 457

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Drug Classes: Antimalarial Agents
• Canonical SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
• Isomeric SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O
• Recent ClinicalTrials: Taste Physiology in Obese Volunteers Before and After Bariatric Surgery
• Recent EU Clinical Trials: Multizentrischer, randomisierter, doppelblinder, Placebo-kontrollierter Parallelgruppenvergleich zum Nachweis der Wirksamkeit und Unbedenklichkeit von Chinin bei Patienten mit Fibromyalgie
• Recent NIPH Clinical Trials: Efficacy and safety of injectable quinine for the treatment of malaria in Japan

Technology Process of Quinine

There total 107 articles about Quinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

quinidine acetate (56652-53-0) → quinindine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.066

Reference yield: 75.0%

(3R,4S)-4-[(2S,3S)-3-(6-Methoxy-quinolin-4-yl)-oxiranylmethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester (865853-19-6) → quinindine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2)

Guidance literature:

With cesium fluoride;

DOI:10.1016/j.tetlet.2005.06.171

Reference yield:

6-Methoxy-4-[(2S,3S)-3-((3R,4S)-3-vinyl-piperidin-4-ylmethyl)-oxiranyl]-quinoline → quinindine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2)

Guidance literature:

In acetonitrile; at 185 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/ja039550y

upstream raw materials:

quinidine

Quinine

O-tosylquinine

water

Downstream raw materials:

(S)-(6-Methoxy-quinolin-4-yl)-((1S,2S,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with [benzyl-(2-oxo-2H-quinolin-1-yl)-amino]-acetic acid

6'-methoxycinchonidone

6'-methoxycinchoninone

viquidil

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 72402-53-0 (6-Methoxy-quinolin-4-yl)-((1S,2S,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send