6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)

Base Information

Chemical Name:6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)
CAS No.:115853-74-2
Molecular Formula:C28H23N2O6.CH3O4S
Molecular Weight:594.58914
Hs Code.:
Mol file:115853-74-2.mol

Synonyms:2',6'-DIMETHYLCARBONYLPHENYL 10-METHYL-9-ACRIDINECARBOXYLATE 4'-NHS ESTER METHYLSULFATE;

Suppliers and Price of 6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 27 raw suppliers

Chemical Property of 6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)

Chemical Property:

Melting Point:228-230℃
PSA：168.67000
LogP:3.98600
Storage Temp.:-20°C

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Novel acridinium esters are disclosed that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays. Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Technology Process of 6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS)

There total 3 articles about 6'-Dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl-10-methyl-acridinium-9-carboxylate methosulfate (DMAE-NHS) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.4%

: 115853-72-0
2',6'-dimethyl-4'-N-succinimidyloxycarbonylphenyl acridine-9-carboxylate

: 77-78-1
dimethyl sulfate

: 115853-74-2
2',6'-Dimethyl-4'-(N-Succinimidyloxycarbonyl)Phenyl 10-Methyl-Acridinium-9-Carboxylate Methosulfate

Guidance literature:: In water; toluene; at 110 ℃; for 20h;

Reference yield:

: 115853-72-0
2',6'-dimethyl-4'-N-succinimidyloxycarbonylphenyl acridine-9-carboxylate

: 115853-74-2
2',6'-Dimethyl-4'-(N-Succinimidyloxycarbonyl)Phenyl 10-Methyl-Acridinium-9-Carboxylate Methosulfate

Guidance literature:: In diethyl ether; dichloromethane;

Reference yield:

: 4919-37-3
3,5-dimethyl-4-hydroxybenzoic acid

: 115853-74-2
2',6'-Dimethyl-4'-(N-Succinimidyloxycarbonyl)Phenyl 10-Methyl-Acridinium-9-Carboxylate Methosulfate

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0 - 5 °C

2: methanesulfonyl chloride; hydrogenchloride / pyridine; water / 100 °C / Inert atmosphere

3: water; toluene / 20 h / 110 °C

With hydrogenchloride; methanesulfonyl chloride; dicyclohexyl-carbodiimide; In pyridine; water; N,N-dimethyl-formamide; toluene;