2-Boc-5-hydroxy-2-azaspiro[3.3]heptane

Base Information

• Chemical Name: 2-Boc-5-hydroxy-2-azaspiro[3.3]heptane
• CAS No.: 1330764-31-2
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.277
• Hs Code.: 2933998090
• Mol file: 1330764-31-2.mol

Synonyms:

Chemical Property of 2-Boc-5-hydroxy-2-azaspiro[3.3]heptane

Chemical Property:

• Boiling Point: 316.6±35.0 °C(Predicted)
• PKA: 14.86±0.20(Predicted)
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Boc-5-hydroxy-2-azaspiro[3.3]heptane

There total 4 articles about 2-Boc-5-hydroxy-2-azaspiro[3.3]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate → tert-butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1330764-31-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1055/s-0035-1562113

Reference yield:

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) → tert-butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1330764-31-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / Inert atmosphere; Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C

3: lithium iodide / tetrahydrofuran / 50 °C / Inert atmosphere

4: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

With sodium tetrahydroborate; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; lithium iodide; In tetrahydrofuran; dichloromethane; water; toluene;

DOI:10.1055/s-0035-1562113

Reference yield:

tert-butyl 3-cyclopropylideneazetidine-1-carboxylate → tert-butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1330764-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C

2: lithium iodide / tetrahydrofuran / 50 °C / Inert atmosphere

3: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; lithium iodide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1055/s-0035-1562113

upstream raw materials:

tert-butyl 3-oxoazetidine-1-carboxylate

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