6-(Piperidin-1-yl)pyrimidin-4-amine

Base Information

• Chemical Name: 6-(Piperidin-1-yl)pyrimidin-4-amine
• CAS No.: 69206-89-9
• Molecular Formula: C9H14N4
• Molecular Weight: 178.23400
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90499202
• Wikidata: Q82349772
• Mol file: 69206-89-9.mol

Synonyms:6-(piperidin-1-yl)pyrimidin-4-amine;69206-89-9;4-Amino-6-piperidinopyrimidine;6-piperidin-1-ylpyrimidin-4-amine;SCHEMBL5889085;DTXSID90499202;REWATXPICITDGX-UHFFFAOYSA-N;MFCD09999227;6-Piperidin-1-yl-pyrimidin-4-ylamine;AKOS006282733;SB41194;DS-10674;CS-0097928;FT-0649333;C76187;EN300-104266;J-514414;F1967-1389;Z1124125441

Chemical Property of 6-(Piperidin-1-yl)pyrimidin-4-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 389.368oC at 760 mmHg
• Flash Point: 189.283oC
• PSA: 55.04000
• Density: 1.185g/cm3
• LogP: 1.69530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 178.121846464
• Heavy Atom Count: 13
• Complexity: 156

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-6-piperidinopyrimidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=NC=NC(=C2)N
• Uses: 6-(1-Piperidinyl)-4-pyrimidinamineis used in the preperation of MNK1/2 inhibitors for cancer therapy.

Technology Process of 6-(Piperidin-1-yl)pyrimidin-4-amine

There total 2 articles about 6-(Piperidin-1-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

piperidine (110-89-4) + 4-amino-6-chloropyrimidine (5305-59-9) → 6-(piperidin-1-yl)pyrimidin-4-amine (69206-89-9)

Guidance literature:

In toluene; for 24h; Heating;

DOI:10.1016/j.bmc.2019.02.007

Reference yield:

→ 6-(piperidin-1-yl)pyrimidin-4-amine (69206-89-9)

Guidance literature:

/BRN= 13018/;

DOI:10.1021/ja01542a037

upstream raw materials:

piperidine

4-amino-6-chloropyrimidine