trilaciclib

Base Information

Chemical Name:trilaciclib
CAS No.:1374743-00-6
Molecular Formula:C₂₄H₃₀N₈O
Molecular Weight:446.555
Hs Code.:

Synonyms:

Suppliers and Price of trilaciclib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Trilaciclib
25mg
$ 485.00

DC Chemicals
G1T28(Trilaciclib) >98%
100 mg
$ 800.00

Total 27 raw suppliers

Chemical Property of trilaciclib

Chemical Property:

Density:1.46±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Trilaciclib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Trilaciclib is a small molecule, competitive inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), with potential antineoplastic and chemoprotective activities.
Uses Trilaciclib is indicated to reduce the frequency of chemotherapy-induced bone marrow suppression in adults receiving certain types of chemotherapy for extensive-stage (when the cancer has spread beyond the lungs) small cell lung cancer.
Drug interactions Trilaciclib is indicated to reduce the incidence of chemotherapy induced myelosuppression in patients prior to receiving platinum and etoposide-containing or topotecan-containing chemotherapy regimens for extensive-stage small cell lung cancer.

Technology Process of trilaciclib

There total 25 articles about trilaciclib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.7%

: 571189-49-6
5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine

: C₁₅H₁₈N₄O₃S

: 1374743-00-6
trilaciclib

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; Inert atmosphere;

Reference yield:

: tert-butyl [(1-aminocyclohexyl)methyl]carbamate

: 1374743-00-6
trilaciclib

Guidance literature:: Multi-step reaction with 10 steps

1: hydrogen; platinum on activated charcoal

2: hydrogenchloride / water

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 60 h

4: dmap / dichloromethane / 3 h / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h

6: triethylamine / dichloromethane / 3 h / Inert atmosphere

7: triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; N,N-dimethyl-formamide / 14 h / 45 - 50 °C / Inert atmosphere

8: trifluoroacetic acid / dichloromethane / 20 °C

9: Oxone / acetonitrile; water

10: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere

With hydrogenchloride; triethylsilane; dmap; Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; platinum on activated charcoal; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1374743-00-6
trilaciclib

Guidance literature:: Multi-step reaction with 10 steps

1.1: titanium(IV) isopropylate; ammonia

2.1: lithium aluminium tetrahydride / tert-butyl methyl ether / 0.5 h / 45 °C

3.1: -70 °C

4.1: hydrogen; platinum on activated charcoal

5.1: hydrogenchloride / water

6.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 24 h / 80 - 85 °C

7.1: dmap / dichloromethane / 3 h / 20 °C

8.1: potassium tert-butylate / tetrahydrofuran / 2.17 h / 20 °C

8.2: 1 h

9.1: Oxone / acetonitrile; water

10.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; dmap; Oxone; lithium aluminium tetrahydride; platinum on activated charcoal; potassium tert-butylate; ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; acetonitrile; tert-butyl alcohol;