Fmoc-(S)β²hAsn(Trt)-OH

Base Information

Chemical Name:Fmoc-(S)β²hAsn(Trt)-OH
CAS No.:756531-87-0
Molecular Formula:C₃₉H₃₄N₂O₅
Molecular Weight:610.709
Hs Code.:

Synonyms:

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Chemical Property of Fmoc-(S)β²hAsn(Trt)-OH

Chemical Property:

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Technology Process of Fmoc-(S)β²hAsn(Trt)-OH

There total 9 articles about Fmoc-(S)β²hAsn(Trt)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637337-12-3
(R)-3-((R)-2-{[(benzyloxy)carbonyl]methyl}-3-[(tert-butoxy)carbonyl]-1-oxopropyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one

: 756531-87-0
Fmoc-(S)β²hAsn(Trt)-OH

Guidance literature:: Multi-step reaction with 9 steps

1.1: 82 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h

2.1: Et₃N; DPPA / toluene

2.2: 76 percent / toluene / 16 h / Heating

3.1: 89 percent / LiOH*H₂O; H₂O₂ / tetrahydrofuran; H₂O / 2 h / 0 °C

4.1: 91 percent / NaHCO₃; Bu₄NI / dimethylformamide / 20 h / 20 °C

5.1: TFA; TES / CH₂Cl₂ / 2 h / 20 °C

6.1: CDI / tetrahydrofuran / 5 h

6.2: 345 mg / NH₃ / tetrahydrofuran

7.1: 85 percent / Ac₂O; H₂SO₄ / acetic acid / 5.5 h / 40 °C

8.1: H₂ / Pd/C / methanol

9.1: 0.36 g / Na₂CO₃ / H₂O; acetone / 4 h / 20 °C / pH 9 - 10

With lithium hydroxide; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; sulfuric acid; diphenyl-phosphinic acid; hydrogen; dihydrogen peroxide; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; sodium carbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1002/hlca.200490142

Reference yield:

: 637337-18-9
tert-butyl (S)-3-({[(benzyloxy)carbonyl]amino}methyl)-4-[(R)-4-(1-methylethyl)-2-oxo-5,5-diphenyloxazolidin-3-yl]-4-oxobutanoate

: 756531-87-0
Fmoc-(S)β²hAsn(Trt)-OH

Guidance literature:: Multi-step reaction with 7 steps

1.1: 89 percent / LiOH*H₂O; H₂O₂ / tetrahydrofuran; H₂O / 2 h / 0 °C

2.1: 91 percent / NaHCO₃; Bu₄NI / dimethylformamide / 20 h / 20 °C

3.1: TFA; TES / CH₂Cl₂ / 2 h / 20 °C

4.1: CDI / tetrahydrofuran / 5 h

4.2: 345 mg / NH₃ / tetrahydrofuran

5.1: 85 percent / Ac₂O; H₂SO₄ / acetic acid / 5.5 h / 40 °C

6.1: H₂ / Pd/C / methanol

7.1: 0.36 g / Na₂CO₃ / H₂O; acetone / 4 h / 20 °C / pH 9 - 10

With lithium hydroxide; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; sulfuric acid; hydrogen; dihydrogen peroxide; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; sodium carbonate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1002/hlca.200490142

Reference yield:

: (S)-2-(Benzyloxycarbonylamino-methyl)-succinic acid 1-benzyl ester

: 756531-87-0
Fmoc-(S)β²hAsn(Trt)-OH

Guidance literature:: Multi-step reaction with 4 steps

1.1: CDI / tetrahydrofuran / 5 h

1.2: 345 mg / NH₃ / tetrahydrofuran

2.1: 85 percent / Ac₂O; H₂SO₄ / acetic acid / 5.5 h / 40 °C

3.1: H₂ / Pd/C / methanol

4.1: 0.36 g / Na₂CO₃ / H₂O; acetone / 4 h / 20 °C / pH 9 - 10

With sulfuric acid; hydrogen; acetic anhydride; sodium carbonate; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetic acid; acetone;
DOI:10.1002/hlca.200490142