(2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

Base Information

• Chemical Name: (2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid
• CAS No.: 1175526-52-9
• Molecular Formula: C₂₇H₂₄F₅NO₅
• Molecular Weight: 537.483
• Mol file: 1175526-52-9.mol

Synonyms:

Chemical Property of (2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

There total 8 articles about (2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester (1175525-91-3) → (2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid (1175526-52-9)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 85 °C

2: sodium cyanoborohydride; acetic acid / methanol

3: N-ethyl-N,N-diisopropylamine / dichloromethane

4: sodium hydroxide / tetrahydrofuran; ethanol

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.01.024

Reference yield:

(2'-formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (1175526-30-3) → (2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid (1175526-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: sodium hydroxide / tetrahydrofuran; ethanol

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.01.024

Reference yield:

C29H28F5NO5 (1347747-30-1) → (2'-{[(3,5-difluoro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid (1175526-52-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2011.01.024

upstream raw materials:

[4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester

(2'-ethylaminomethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester

C₈H₅ClF₂O₂

C₂₉H₂₈F₅NO₅