Technology Process of (2S)-2-amino-N-(2-aminoethyl)-3-(4-chlorophenyl)-N-(spiro[5.5]undecan-3-yl)propanamide trifluoroacetic acid salt
There total 1 articles about (2S)-2-amino-N-(2-aminoethyl)-3-(4-chlorophenyl)-N-(spiro[5.5]undecan-3-yl)propanamide trifluoroacetic acid salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(spiro[5.5]undecan-3-yl)ethylenediamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
para-Chloro-D-phenylalanine;
With
N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
dichloromethane;
at 20 ℃;
for 20h;
trifluoroacetic acid;
With
chlorotriisopropylsilane; ethane-1,2-dithiol;
In
water;
at 20 ℃;
for 1h;
Further stages.;
DOI:10.1016/j.bmc.2007.06.003