Technology Process of (R,S)-N-hydroxy-3,5-dioxo-6-(phenylmethyl)spiro[piperazine-2,2'-tricyclo[3.3.1.13,7]decane]-4-acetamide hydrochloride
There total 8 articles about (R,S)-N-hydroxy-3,5-dioxo-6-(phenylmethyl)spiro[piperazine-2,2'-tricyclo[3.3.1.13,7]decane]-4-acetamide hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: water; dimethyl sulfoxide / 48 h / 20 °C
2.1: sulfuric acid / dichloromethane / 48 h / 20 °C
3.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
3.2: 48 h / 20 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 28 °C / Inert atmosphere
5.2: 25 h / 28 - 45 °C / Inert atmosphere
6.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / 2585.81 Torr
7.1: hydrogenchloride / diethyl ether / Cooling with ice
With
hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
1.1: Strecker reaction;
DOI:10.1021/jm200217m
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / 2585.81 Torr
2: hydrogenchloride / diethyl ether / Cooling with ice
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen;
In
diethyl ether; ethanol;
DOI:10.1021/jm200217m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / dichloromethane / 48 h / 20 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 48 h / 20 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 28 °C / Inert atmosphere
4.2: 25 h / 28 - 45 °C / Inert atmosphere
5.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / 2585.81 Torr
6.1: hydrogenchloride / diethyl ether / Cooling with ice
With
hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm200217m
