(3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Base Information

Chemical Name:(3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid
CAS No.:1268841-36-6
Molecular Formula:C₃₂H₃₃ClFN₃O₆
Molecular Weight:610.082
Hs Code.:

(3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Synonyms:

Suppliers and Price of (3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

There total 10 articles about (3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78607-32-6
3-amino-2,5-dichloropyridine

: 1268841-36-6
(3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine; tetrabutylammomium bromide / 1,4-di(diphenylphosphino)-butane; palladium diacetate / N,N-dimethyl-formamide / 30 h / 140 °C

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

2.2: 1.5 h / 40 °C

2.3: 1.7percent palladium-fibroin / 18 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.17 h / -78 °C / cooling with ice

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.58 h / -78 °C / cooling with ice

5.2: 0.67 h / 20 °C / cooling with ice

6.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.67 h / Reflux

7.1: sodium hydrogencarbonate / dimethyl sulfoxide / 6 h / 100 °C

7.2: 1.83 h

8.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With N-Bromosuccinimide; potassium tert-butylate; tetrabutylammomium bromide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; 2,2'-azobis(isobutyronitrile); palladium diacetate; 1,4-di(diphenylphosphino)-butane; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Heck Reaction;

Reference yield:

: 959616-22-9
ethyl (E)-3-(3-amino-5-chloropyridin-2-yl)prop-2-enoate

: 1268841-36-6
(3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

1.2: 1.5 h / 40 °C

1.3: 1.7percent palladium-fibroin / 18 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.17 h / -78 °C / cooling with ice

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.58 h / -78 °C / cooling with ice

4.2: 0.67 h / 20 °C / cooling with ice

5.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.67 h / Reflux

6.1: sodium hydrogencarbonate / dimethyl sulfoxide / 6 h / 100 °C

6.2: 1.83 h

7.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With N-Bromosuccinimide; potassium tert-butylate; sodium hydrogencarbonate; trifluoroacetic acid; lithium hexamethyldisilazane; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1268842-00-7
tert-butyl 4-{[5-chloro-2-(3-ethoxy-3-oxopropyl)pyridin-3-yl]amino}piperidine-1-carboxylate

: 1268841-36-6
(3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.17 h / -78 °C / cooling with ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.58 h / -78 °C / cooling with ice

3.2: 0.67 h / 20 °C / cooling with ice

4.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.67 h / Reflux

5.1: sodium hydrogencarbonate / dimethyl sulfoxide / 6 h / 100 °C

5.2: 1.83 h

6.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With N-Bromosuccinimide; potassium tert-butylate; sodium hydrogencarbonate; trifluoroacetic acid; lithium hexamethyldisilazane; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide;