Technology Process of 5-(3,5-difluorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide
There total 4 articles about 5-(3,5-difluorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; tricyclohexylphosphine;
In
1,4-dioxane;
at 95 ℃;
for 24h;
DOI:10.1016/j.bmcl.2013.10.045
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium hydroxide / tetrahydrofuran; methanol / 24 h / 25 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 100 °C
3: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 24 h / 95 °C
With
tris-(dibenzylideneacetone)dipalladium(0); benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.10.045
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 100 °C
2: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 24 h / 95 °C
With
tris-(dibenzylideneacetone)dipalladium(0); benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine;
In
1,4-dioxane; N,N-dimethyl-formamide;
2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.10.045
