PDD00017273

Base Information

Chemical Name:PDD00017273
CAS No.:1945950-21-9
Molecular Formula:C₂₃H₂₆N₆O₄S₂
Molecular Weight:514.629
Hs Code.:

Synonyms:

Suppliers and Price of PDD00017273

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PDD00017273
25mg
$ 150.00

Tocris
PDD00017273 ≥98%(HPLC)
1
$ 125.00

Tocris
PDD00017273 ≥98%(HPLC)
10
$ 292.00

Adipogen Life Sciences
PARGInhibitorPDD00017273 ≥98%(HPLC)
5 mg
$ 180.00

Total 10 raw suppliers

Chemical Property of PDD00017273

Chemical Property:

Boiling Point:733.9±70.0 °C(Predicted)
Density:1.52±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

PDD00017273 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses PDD 00017273 is used as a chemical probe against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacol. to olaparib.

Technology Process of PDD00017273

There total 10 articles about PDD00017273 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 852227-86-2
5-(chloromethyl)-1,3-dimethyl-1H-pyrazole

: N-(1-methylcyclopropyl)-3-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-1H-quinazoline-6-sulfonamide

: 1945950-21-9
PDD00017273

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/acschembio.6b00609

Reference yield: 43.0%

: N-(1-methylcyclopropyl)-3-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-1H-quinazoline-6-sulfonamide

: 57012-20-1
(1,3-dimethyl-1H-pyrazol-5-yl)methanol

: 1945950-21-9
PDD00017273

Guidance literature:: With di-isopropyl azodicarboxylate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.jmedchem.8b01407

Reference yield:

: 118-48-9
isatoic anhydride

: 1945950-21-9
PDD00017273

Guidance literature:: Multi-step reaction with 5 steps

1: trimethylamine / N,N-dimethyl-formamide / 3 h / 50 °C

2: trimethylamine / tetrahydrofuran / 16 h / 20 °C

3: chlorosulfonic acid / 3 h / 60 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dichloromethane / 3 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C / Microwave irradiation

With chlorosulfonic acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; trimethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acschembio.6b00609