6-phenylamino-6-deoxyfumagillol

Base Information

• Chemical Name: 6-phenylamino-6-deoxyfumagillol
• CAS No.: 132658-34-5
• Molecular Formula: C₂₂H₃₁NO₃
• Molecular Weight: 357.493
• Mol file: 132658-34-5.mol

Synonyms:

Chemical Property of 6-phenylamino-6-deoxyfumagillol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-phenylamino-6-deoxyfumagillol

There total 2 articles about 6-phenylamino-6-deoxyfumagillol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

Fumaginone (132746-88-4) + aniline (62-53-3) → 6-phenylamino-6-deoxyfumagillol (132658-34-5)

Guidance literature:

With 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In methanol; for 1h;

DOI:10.1248/cpb.40.575

Reference yield:

fumagillol (35903-52-7,128656-25-7,132746-73-7,108102-51-8) → 6-phenylamino-6-deoxyfumagillol (132658-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / CrO₃*pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 54 percent / NaBH₃CN, molecular sieves 3A, AcOH / methanol / 1 h

With chromium trioxide-pyridine complex; 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane;

DOI:10.1248/cpb.40.575

upstream raw materials:

Fumaginone

aniline

fumagillol