Technology Process of 2-[4-(cyclopentylthio)-2-fluorophenyl]propanoic acid
There total 8 articles about 2-[4-(cyclopentylthio)-2-fluorophenyl]propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
methanol;
Reflux;
DOI:10.1021/jm300049g
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride / water / 3 h / Reflux
2.1: palladium 10% on activated carbon; hydrogen / 12 h / 20 °C / 760.05 Torr
3.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C
3.2: 1 h / 50 °C
4.1: potassium hydroxide / ethanol / 2 h / Reflux
4.2: pH 1
5.1: hydrogenchloride / water / 3 h / Reflux
6.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C
7.1: water; sodium hydroxide / methanol / Reflux
With
hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; potassium hydroxide; sodium hydroxide; sodium nitrite;
In
methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300049g
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydroxide / N,N-dimethyl-formamide / 6 h / 20 °C
2.1: sulfuric acid; water; acetic acid / 12 h / Reflux
3.1: hydrogenchloride / water / 3 h / Reflux
4.1: palladium 10% on activated carbon; hydrogen / 12 h / 20 °C / 760.05 Torr
5.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C
5.2: 1 h / 50 °C
6.1: potassium hydroxide / ethanol / 2 h / Reflux
6.2: pH 1
7.1: hydrogenchloride / water / 3 h / Reflux
8.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C
9.1: water; sodium hydroxide / methanol / Reflux
With
hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; acetic acid; potassium hydroxide; sodium hydroxide; sodium nitrite;
In
methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300049g
