C₂₂H₂₀N₂O₃S

Base Information

• Chemical Name: C₂₂H₂₀N₂O₃S
• CAS No.: 1374689-49-2
• Molecular Formula: C₂₂H₂₀N₂O₃S
• Molecular Weight: 392.478
• Mol file: 1374689-49-2.mol

Synonyms:

Chemical Property of C₂₂H₂₀N₂O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀N₂O₃S

There total 13 articles about C₂₂H₂₀N₂O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H34N2O3SSi → C22H20N2O3S (1374689-49-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.12.019

Reference yield:

4-fluorobenzaldehyde (459-57-4) → C22H20N2O3S (1374689-49-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

2: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; water / tetrahydrofuran; tert-butyl alcohol

3: benzotriazol-1-ol / acetonitrile

4: tetrabutyl ammonium fluoride / tetrahydrofuran

With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; water; potassium carbonate; benzotriazol-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 2: Pinnick oxidation;

DOI:10.1016/j.bmcl.2011.12.019

Reference yield:

4-Bromothiophen-2-aldehyde (18791-75-8) → C22H20N2O3S (1374689-49-2)

Guidance literature:

Multi-step reaction with 9 steps

1: sodium tetrahydroborate / methanol

2: 1H-imidazole / N,N-dimethyl-formamide

3: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / tetrahydrofuran

4: n-butyllithium / tetrahydrofuran / Large scale reaction

5: hydroxylamine hydrochloride; triethylamine / methanol; dichloromethane

6: dicyclohexyl-carbodiimide / toluene / 90 °C

7: hydroxylamine / ethanol; water

8: benzotriazol-1-ol / acetonitrile

9: tetrabutyl ammonium fluoride / tetrahydrofuran

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; hydroxylamine; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2011.12.019

upstream raw materials:

4-Bromothiophen-2-aldehyde

5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-ethylthiophene-2-carboxaldehyde

C₁₄H₂₅NO₂SSi

4-(2-methylphenoxy)benzoic acid