(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt

Base Information

Chemical Name:(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt
CAS No.:1404473-71-7
Molecular Formula:C₂₂H₂₄BrN₆O₇S₂*Na
Molecular Weight:651.494
Hs Code.:

(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt

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Chemical Property of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt

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Technology Process of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt

There total 9 articles about (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 958025-66-6
MPC-3100

: 1404473-71-7
(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt

Guidance literature:: MPC-3100; With chlorosulfonic acid; diisopropyl-carbodiimide; dmap; In pyridine; N,N-dimethyl-formamide; at 20 ℃; for 18h;

With sodium hydroxide; In water;

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 1404473-71-7
(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: tetrahydrofuran; methanol / 20 °C / NaOAc-AcOH buffer

2.2: 2 h / 20 °C

3.1: silver carbonate / N,N-dimethyl-formamide / 100 °C

4.1: bromine / acetic acid / 1 h / 20 °C

4.2: 1 h

5.1: triethylamine / dichloromethane; tetrahydrofuran / 20 °C

5.2: 6 h

6.1: diisopropyl-carbodiimide; chlorosulfonic acid / dmap / N,N-dimethyl-formamide; pyridine / 18 h / 20 °C

With chlorosulfonic acid; bromine; caesium carbonate; triethylamine; silver carbonate; diisopropyl-carbodiimide; dmap; In tetrahydrofuran; pyridine; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 8-((6-bromobenzo[d][1,3]dioxol-5-yl)thio)-9-(2-(piperidin-4-yl)ethyl)-9H-purin-6-amine

: 1404473-71-7
(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl hydrogen sulfate sodium salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane; tetrahydrofuran / 20 °C

1.2: 6 h

2.1: diisopropyl-carbodiimide; chlorosulfonic acid / dmap / N,N-dimethyl-formamide; pyridine / 18 h / 20 °C

With chlorosulfonic acid; triethylamine; diisopropyl-carbodiimide; dmap; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;