(2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

Base Information

Chemical Name:(2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester
CAS No.:769950-32-5
Molecular Formula:C₃₁H₃₉ClO₄
Molecular Weight:511.101
Hs Code.:

(2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

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Suppliers and Price of (2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

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Chemical Property of (2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

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Technology Process of (2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

There total 5 articles about (2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.7%

: 769950-27-8
(2E)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enoic acid 4-chlorophenyl ester

: 769950-32-5
(2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

Guidance literature:: With lithium carbonate; In N,N-dimethyl acetamide; for 0.5h; Heating;
DOI:10.1002/hlca.200490163

Reference yield:

: 54815-36-0
jujubogenin

: 769950-32-5
(2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: HCl / ethanol; H₂O / 5 h / 80 °C

2.1: pyridine / 10 h / 0 °C

3.1: O₃ / CH₂Cl₂; methanol / 1 h / -78 °C

3.2: Me₂S / CH₂Cl₂; methanol / 2 h / -10 - 0 °C

4.1: NBS / CCl₄ / 0.08 h / Irradiation

4.2: 43 percent / Et₃N / CCl₄ / 1 h / 20 °C

5.1: 41.7 percent / Li₂CO₃ / N,N-dimethyl-acetamide / 0.5 h / Heating

With pyridine; hydrogenchloride; N-Bromosuccinimide; lithium carbonate; ozone; In methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1002/hlca.200490163

Reference yield:

: (20E)-3-O-(methylsulfonyl)-22-secoebelin-22-al lactone

: 769950-32-5
(2E)-3-[(1'S,2'R,4'aR,4'bS,,8'aS,10'aR)-3'4,4'4'a,4'b,5,5',8',8'a,9',10',10'a-dodecahydro-4'b,8',8',10'a-tetramethyl-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]-2-methylprop-2-enoic acid 4-chlorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NBS / CCl₄ / 0.08 h / Irradiation

1.2: 43 percent / Et₃N / CCl₄ / 1 h / 20 °C

2.1: 41.7 percent / Li₂CO₃ / N,N-dimethyl-acetamide / 0.5 h / Heating

With N-Bromosuccinimide; lithium carbonate; In tetrachloromethane; N,N-dimethyl acetamide;
DOI:10.1002/hlca.200490163