ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Base Information

• Chemical Name: ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS No.: 1373767-31-7
• Molecular Formula: C₂₄H₁₇Cl₂NO₃
• Molecular Weight: 438.31
• Mol file: 1373767-31-7.mol

Synonyms:

Chemical Property of ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 8 articles about ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H16Cl3NO2 → ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1373767-31-7)

Guidance literature:

With acetic acid; In water; at 120 ℃; for 1h;

DOI:10.1021/jm201642z

Reference yield:

C12H8Cl3NO2 (476194-52-2) → ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1373767-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 24 °C

2: phosphorus(V) oxybromide / chloroform / 1 h / 24 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 3 h / 75 °C

4: acetic acid / water / 1 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; phosphorus(V) oxybromide; In 1,4-dioxane; chloroform; water; 3: Suzuki coupling;

DOI:10.1021/jm201642z

Reference yield:

C12H8Cl3NO3 → ethyl 2-([1,1'-biphenyl]-3-yl)-6,7-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1373767-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / chloroform / 1 h / 24 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 3 h / 75 °C

3: acetic acid / water / 1 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; acetic acid; phosphorus(V) oxybromide; In 1,4-dioxane; chloroform; water; 2: Suzuki coupling;

DOI:10.1021/jm201642z

upstream raw materials:

C₁₂H₈Cl₃NO₂

C₁₂H₇BrCl₃NO₂

diethyl 2-(((3,4 -dichlorophenyl)amino)methylene)malonate

diethyl 2-ethoxymethylenemalonate