3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine

Base Information

Chemical Name:3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine
CAS No.:105166-11-8
Molecular Formula:C₃₃H₅₁N₅O₇SSi₂
Molecular Weight:718.034
Hs Code.:

3',5'-O-TIPDS-N<sup>2</sup>-acetyl-O<sup>6</sup>-ethyl-2'(R)-phenylthiomethylguanosine

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine

Chemical Property:

Purity/Quality:

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Technology Process of 3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine

There total 5 articles about 3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 105166-11-8
3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / 3 h / Ambient temperature

2: 69 percent / DMSO, (COCl)2 / CH₂Cl₂ / 0.5 h / -70 - -60 °C

3: 15 percent / tetrahydrofuran; dimethylsulfoxide / 2.5 h / Ambient temperature

4: 1.) N-methylmorpholine-N-oxide, OsO₄; 2.) MsCl, pyridine; 3.) KOtBu

With pyridine; osmium(VIII) oxide; oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1248/cpb.34.1961

Reference yield:

: 105166-09-4
2-acetamido-6-ethoxy-9-(β-D-ribofuranosyl)-9H-purine

: 105166-11-8
3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / 3 h / Ambient temperature

2: 69 percent / DMSO, (COCl)2 / CH₂Cl₂ / 0.5 h / -70 - -60 °C

3: 15 percent / tetrahydrofuran; dimethylsulfoxide / 2.5 h / Ambient temperature

4: 1.) N-methylmorpholine-N-oxide, OsO₄; 2.) MsCl, pyridine; 3.) KOtBu

With pyridine; osmium(VIII) oxide; oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1248/cpb.34.1961

Reference yield:

: 105186-62-7
3',5'-O-TIPDS-N²-acetyl-O⁶-ethylguanosine

: 105166-11-8
3',5'-O-TIPDS-N²-acetyl-O⁶-ethyl-2'(R)-phenylthiomethylguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / DMSO, (COCl)2 / CH₂Cl₂ / 0.5 h / -70 - -60 °C

2: 15 percent / tetrahydrofuran; dimethylsulfoxide / 2.5 h / Ambient temperature

3: 1.) N-methylmorpholine-N-oxide, OsO₄; 2.) MsCl, pyridine; 3.) KOtBu

With pyridine; osmium(VIII) oxide; oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1248/cpb.34.1961