9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

Base Information

• Chemical Name: 9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one
• CAS No.: 1260403-38-0
• Molecular Formula: C₂₄H₂₃Br₂NO₇
• Molecular Weight: 597.257
• Mol file: 1260403-38-0.mol

Synonyms:

Chemical Property of 9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

There total 7 articles about 9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H29NO12S2 → 9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-38-0)

Guidance literature:

With lithium bromide; In acetone; at 20 ℃; for 48h;

DOI:10.1002/cmdc.201000305

Reference yield:

9-[1,2-dihydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-37-9) → 9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

2: lithium bromide / acetone / 48 h / 20 °C

With triethylamine; lithium bromide; In dichloromethane; acetone;

DOI:10.1002/cmdc.201000305

Reference yield:

3,4,5-trimethoxycinnamaldehyde (71277-13-9,34346-90-2,71277-12-8) → 9-[1,2-dibromo-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-38-0)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 10 h / Reflux

2: dichloromethane / 1 h / Reflux

3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetonitrile; tert-butyl alcohol / 24 h / 20 °C

4: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

5: lithium bromide / acetone / 48 h / 20 °C

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; triethylamine; lithium bromide; In ethanol; dichloromethane; water; acetone; acetonitrile; tert-butyl alcohol;

DOI:10.1002/cmdc.201000305

upstream raw materials:

3-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enylidene]-furane-2,4(3H,5H)-dione

9-[1,2-dihydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-6,7-(methylenedioxy)-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

6,7-(methylenedioxy)-9-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

(E)-3,4,5-trimethoxy-cinnamic acid

Downstream raw materials:

4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethynyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one