{2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

Base Information

• Chemical Name: {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone
• CAS No.: 1027493-22-6
• Molecular Formula: C₂₄H₂₂Cl₂F₃N₃OS
• Molecular Weight: 528.425
• Mol file: 1027493-22-6.mol

Synonyms:

Chemical Property of {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

There total 4 articles about {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-{3-(4-chlorobenzoyl)-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione (1394867-83-4) → {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone (1027493-22-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Inert atmosphere; Reflux;

DOI:10.1021/jm3007504

Reference yield:

(2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone (50508-66-2) → {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone (1027493-22-6)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 18 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice

4: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; acetic acid; acetonitrile;

DOI:10.1021/jm3007504

Reference yield:

2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-methylthiophen-2-yl]isoindoline-1,3-dione (1027493-34-0) → {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone (1027493-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice

2: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane;

DOI:10.1021/jm3007504

upstream raw materials:

(2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone

2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-methylthiophen-2-yl]isoindoline-1,3-dione

2-{3-(4-chlorobenzoyl)-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

2-[3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl]isoindoline-1,3-dione