(R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Chemical Name:(R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
CAS No.:1189569-16-1
Molecular Formula:C₃₄H₃₄F₂N₄O₂
Molecular Weight:568.666
Hs Code.:

(R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Chemical Property of (R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Technology Process of (R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

There total 8 articles about (R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1189569-02-5
(2R)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

: 1189569-16-1
(R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 50 ℃; for 16h;
DOI:10.1021/ml400199p

Reference yield:

: 321318-29-0,444643-16-7,771465-40-8
1-(3,5-difluorophenyl)ethylamine

: 1189569-16-1
(R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 0 - 20 °C

1.2: 3 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

4.1: acetic acid / methanol / 0.5 h / 20 °C

4.2: 0.5 h / pH 5

5.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

6.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

7.2: 18 h / 20 °C

8.1: N-Methyldicyclohexylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 0.33 h / 150 °C / Microwave irradiation; Inert atmosphere

9.1: acetic acid; sodium cyanoborohydride / methanol / 16 h / 50 °C

With hydrogenchloride; lithium aluminium tetrahydride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; potassium tert-butylate; sodium hydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400199p

Reference yield:

: 957122-13-3
di-tert-butyl [1-(3,5-difluorophenyl)ethyl]imidodicarbonate

: 1189569-16-1
(R)-5-((E)-3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-en-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

3.1: acetic acid / methanol / 0.5 h / 20 °C

3.2: 0.5 h / pH 5

4.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

5.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

6.2: 18 h / 20 °C

7.1: N-Methyldicyclohexylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 0.33 h / 150 °C / Microwave irradiation; Inert atmosphere

8.1: acetic acid; sodium cyanoborohydride / methanol / 16 h / 50 °C

With hydrogenchloride; lithium aluminium tetrahydride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; potassium tert-butylate; sodium hydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400199p