4-Piperidinone,3-fluoro,HCl

Base Information

• Chemical Name: 4-Piperidinone,3-fluoro,HCl
• CAS No.: 1070896-59-1
• Molecular Formula: C5H8FNO^.HCl
• Molecular Weight: 153.58
• Hs Code.: 2933399990
• Mol file: 1070896-59-1.mol

Synonyms:3-fluoropiperidin-4-one hydrochloride;4-piperidinone, 3-fluoro-, hydrochloride (1:1);

Chemical Property of 4-Piperidinone,3-fluoro,HCl

Chemical Property:

• Boiling Point: 214.5 °C at 760 mmHg
• Flash Point: 83.5 °C
• PSA: 29.10000
• LogP: 1.01770

Purity/Quality:

99%, ^*data from raw suppliers

3-Fluoro-4-piperidinoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluoro-4-piperidinone, HCl

Technology Process of 4-Piperidinone,3-fluoro,HCl

There total 3 articles about 4-Piperidinone,3-fluoro,HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate (211108-50-8) → 3-fluoropiperidin-4-one hydrochloride (1070896-59-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 16h;

Reference yield:

tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate (211108-48-4) → 3-fluoropiperidin-4-one hydrochloride (1070896-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Selectfluor / acetonitrile / 1.25 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; Selectfluor; In 1,4-dioxane; acetonitrile;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 3-fluoropiperidin-4-one hydrochloride (1070896-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C

2: Selectfluor / acetonitrile / 1.25 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; Selectfluor; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-one

benzyl 3-fluoro-4-oxopiperidine-1-carboxylate

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