N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

Base Information

Chemical Name:N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
CAS No.:1072959-67-1
Molecular Formula:C22H24 N4 O4
Molecular Weight:408.457
Hs Code.:
Mol file:1072959-67-1.mol

Synonyms:SR 3677

Suppliers and Price of N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SR 3677 dihydrochloride
10mg
$ 531.00

TRC
SR 3677
10mg
$ 160.00

Tocris
SR3677dihydrochloride ≥98%(HPLC)
50
$ 1088.00

Tocris
SR3677dihydrochloride ≥98%(HPLC)
10
$ 272.00

Sigma-Aldrich
SR 3677 ≥98% (HPLC)
5mg
$ 127.00

Sigma-Aldrich
SR 3677 ≥98% (HPLC)
25mg
$ 488.00

Medical Isotopes, Inc.
SR 3677
5 mg
$ 610.00

Matrix Scientific
N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide 95%
10g
$ 12026.00

Matrix Scientific
N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide 95%
5g
$ 7586.00

DC Chemicals
SR 3677 >98%
250 mg
$ 750.00

Total 26 raw suppliers

Chemical Property of N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

Chemical Property:

Boiling Point:646.9±55.0 °C(Predicted)
PKA:11.90±0.70(Predicted)
PSA：92.20000
Density:1.298
LogP:3.44510
Storage Temp.:Desiccate at RT
Solubility.:DMSO: soluble15mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

SR 3677 dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Uses SR 3677 is an ATP-competitive inhibitor of Rho-kinases (ROCK-I/ROCK-II) which reduces amyloid-β production. It’s hypothesized that Alzheimer’s Disease, can be treated with this type of treatment, and delay further progression of the disease.

Technology Process of N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

There total 1 articles about N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 1072906-06-9
N-(4-bromo-2-(2-(dimethylamino)ethoxy)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

: 1072959-67-1
SR 3677

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 - 100 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm800986w