N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid

Base Information

Chemical Name:N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid
CAS No.:130296-53-6
Molecular Formula:C₂₅H₂₃FN₄O₇
Molecular Weight:510.479
Hs Code.:

N-<4-<N-<<3,4-dihydro-2-(hydroxymethyl)-4-oxo-6-quinazolinyl>methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid

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Chemical Property of N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid

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Technology Process of N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid

There total 7 articles about N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 130296-58-1
diethyl N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

: 130296-53-6
N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid

Guidance literature:: With sodium hydroxide; for 4h;
DOI:10.1021/jm00173a025

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 130296-53-6
N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 57 percent / Na₂Cr₂O₇, cocnd. H₂SO₄ / acetic acid / 1 h / 90 °C

2: SOCl₂ / toluene / 1.5 h / Heating

3: Et₃N / CH₂Cl₂ / 2 h / 25 °C

4: 95 percent / iron powder, HOAc / 2 h / 50 °C

5: 60 percent / K₂CO₃ / toluene; dimethylformamide / 3 h / 110 - 120 °C

6: 12 percent / 2,6-lutidine / dimethylformamide / 24 h / 80 °C

7: 46 percent / 1 N aq. NaOH / 4 h

With 2,6-dimethylpyridine; sodium hydroxide; thionyl chloride; sodium dichromate; sulfuric acid; iron; potassium carbonate; acetic acid; triethylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a025

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 130296-53-6
N-<4-methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / toluene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 2 h / 25 °C

3: 95 percent / iron powder, HOAc / 2 h / 50 °C

4: 60 percent / K₂CO₃ / toluene; dimethylformamide / 3 h / 110 - 120 °C

5: 12 percent / 2,6-lutidine / dimethylformamide / 24 h / 80 °C

6: 46 percent / 1 N aq. NaOH / 4 h

With 2,6-dimethylpyridine; sodium hydroxide; thionyl chloride; iron; potassium carbonate; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a025