2,4-Dichloro-7-methoxy-8-methylquinoline

Base Information

• Chemical Name: 2,4-Dichloro-7-methoxy-8-methylquinoline
• CAS No.: 1108659-32-0
• Molecular Formula: C11H9 Cl2 N O
• Molecular Weight: 242.10100
• DSSTox Substance ID: DTXSID80694729
• Wikidata: Q72466663
• Mol file: 1108659-32-0.mol

Synonyms:1108659-32-0;2,4-DICHLORO-7-METHOXY-8-METHYLQUINOLINE;2,4-dichloro-7-methoxy-8-methyl-quinoline;SCHEMBL314537;DTXSID80694729;LXMBJRUBTLFCFT-UHFFFAOYSA-N;MFCD12405607;AKOS037643841;AS-37668;2,4-dichloro-8-methyl-7-methoxyquinoline;CS-0173089;FT-0743650;A802261

Chemical Property of 2,4-Dichloro-7-methoxy-8-methylquinoline

Chemical Property:

• PSA: 22.12000
• Density: 1.337
• LogP: 3.85860
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 241.0061193
• Heavy Atom Count: 15
• Complexity: 227

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-7-methoxy-8-methyl-quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC2=C1N=C(C=C2Cl)Cl)OC

Technology Process of 2,4-Dichloro-7-methoxy-8-methylquinoline

There total 3 articles about 2,4-Dichloro-7-methoxy-8-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

malonic acid (141-82-2) + 3-methoxy-2-methyl-aniline; hydrochloride (857195-15-4) → 2,4-dichloro-8-methyl-7-methoxyquinoline (1108659-32-0)

Guidance literature:

With trichlorophosphate; for 16h; Heating / reflux;

Reference yield: 43.0%

→ 2,4-dichloro-8-methyl-7-methoxyquinoline (1108659-32-0)

Guidance literature:

Reference yield:

malonic acid (141-82-2) + 2-methyl-3-methoxyaniline (19500-02-8) → 2,4-dichloro-8-methyl-7-methoxyquinoline (1108659-32-0)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1016/j.bmcl.2015.07.020

upstream raw materials:

malonic acid

3-methoxy-2-methyl-aniline; hydrochloride

2-methyl-3-methoxyaniline

Downstream raw materials:

2-chloro-8-methyl-7-methoxy-4-(4-methoxybenzyloxy)quinoline

8-chloro-7-methoxy-4-(4-methoxy-benzyloxy)-2-(3-trifluoromethyl-1H-pyrazol-1-yl)-quinoline