Technology Process of (3aR,6aS,7aR,8R,11aR,11bS,11cR)-2,10-Dimethoxy-3,8,11a,11c-tetramethyl-3a,6a,7,7a,8,11a,11b,11c-octahydro-4H-6-oxa-benzo[de]anthracene-1,5,11-trione
There total 67 articles about (3aR,6aS,7aR,8R,11aR,11bS,11cR)-2,10-Dimethoxy-3,8,11a,11c-tetramethyl-3a,6a,7,7a,8,11a,11b,11c-octahydro-4H-6-oxa-benzo[de]anthracene-1,5,11-trione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-dichloro-benzonitrile;
In
benzene;
for 3.3h;
- Guidance literature:
-
With
acetic acid;
Yield given. Multistep reaction;
1.) reflux, 25 min; 2.) reflux, 2 h;
DOI:10.1021/ja00324a023
- Guidance literature:
-
Multi-step reaction with 7 steps
1: i-Bu2AlH / toluene / 0.5 h / -78 °C
2: 92 percent / HCl / 30 h / 0 °C
3: 1.) B2H6; 2.) H2O2, aq. NaOH / 1.) THF, 0 deg C, 30 min then room temp., 2 h; 2.) 50 deg C, 45 min
4: 78 percent / CrO3/pyridine / CH2Cl2 / 30 h / 0 °C
5: 35 percent / LDA, MoO5.py.HMPA / tetrahydrofuran / 15 h / 0 °C
6: 57 percent / NaOMe / dimethylsulfoxide; methanol / 15 h / 10 °C
7: 1.) AcOH; 2.) Fetizon's reagent / 1.) reflux, 25 min; 2.) reflux, 2 h
With
pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; dihydrogen peroxide; sodium methylate; diisobutylaluminium hydride; acetic acid; diborane; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja00324a023
