(2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol

Base Information

Chemical Name:(2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol
CAS No.:101376-84-5
Molecular Formula:C₃₂H₄₂O₃
Molecular Weight:474.684
Hs Code.:

Synonyms:

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Chemical Property of (2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol

Chemical Property:

Purity/Quality:

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Hazard Codes:

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Technology Process of (2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol

There total 13 articles about (2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101376-83-4,101470-18-2,125590-07-0
(2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraenoic acid methyl ester

: 101376-84-5,101469-64-1,125590-08-1
(2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at -78 ℃;
DOI:10.1021/jo00359a060

Reference yield:

: 70238-41-4
(E)-4-(benzyloxy)-2-methylbut-2-en-1-ol

: 101376-84-5,101469-64-1,125590-08-1
(2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol

Guidance literature:: Multi-step reaction with 11 steps

1: (COCl)2, Me₂SO, Et₃N / CH₂Cl₂

2: -78 °C

3: Bu₄NF / tetrahydrofuran / 0 - 23 °C

4: n-BuLi / tetrahydrofuran / -78 °C

5: tetrahydrofuran / -40 °C

6: red-Al / diethyl ether / 0 - 23 °C

7: n-BuLi, HMPA / tetrahydrofuran

8: Bu₄NF / tetrahydrofuran / 23 °C

9: (COCl)2, Me₂SO, Et₃N / CH₂Cl₂

10: CH₂Cl₂

11: DIBAH / diethyl ether / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00359a060

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 101376-84-5,101469-64-1,125590-08-1
(2E,8E,10E,12E)-(4R,6R)-7,14-Bis-benzyloxy-2,4,6,12-tetramethyl-tetradeca-2,8,10,12-tetraen-1-ol

Guidance literature:: Multi-step reaction with 13 steps

1: CH₂Cl₂

2: DIBAH / diethyl ether / -78 °C

3: (COCl)2, Me₂SO, Et₃N / CH₂Cl₂

4: -78 °C

5: Bu₄NF / tetrahydrofuran / 0 - 23 °C

6: n-BuLi / tetrahydrofuran / -78 °C

7: tetrahydrofuran / -40 °C

8: red-Al / diethyl ether / 0 - 23 °C

9: n-BuLi, HMPA / tetrahydrofuran

10: Bu₄NF / tetrahydrofuran / 23 °C

11: (COCl)2, Me₂SO, Et₃N / CH₂Cl₂

12: CH₂Cl₂

13: DIBAH / diethyl ether / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00359a060