2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE

Base Information

• Chemical Name: 2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE
• CAS No.: 1151564-03-2
• Molecular Formula: C13H18 B Cl O3
• Molecular Weight: 268.548
• Hs Code.: 2934999090
• Mol file: 1151564-03-2.mol

Synonyms:2-(2-chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;

Chemical Property of 2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE

Chemical Property:

• PSA: 27.69000
• LogP: 2.64780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE

There total 1 articles about 2-(2-CHLORO-3-METHOXYPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (1151564-17-8) + dimethyl sulfate (77-78-1) → (2-chloro-3-methoxyphenyl)boronic acid pinacol ester (1151564-03-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 28 - 55 ℃; for 0.666667h;

Reference yield: 82.1%

(2-chloro-3-methoxyphenyl)boronic acid pinacol ester (1151564-03-2) + C14H11F3N4O4S → 6-(2-chloro-3-methoxyphenyl)-2-(5-methylpyrimidin-2-yl)-7,8-dihydrophthalazin-1(2H)-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; at 70 ℃; for 3h; Inert atmosphere;

Reference yield: 70.0%

(2-chloro-3-methoxyphenyl)boronic acid pinacol ester (1151564-03-2) + 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione (1150560-54-5) → 5-(2-chloro-3-methoxy-phenyl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione (1150560-56-7)

Guidance literature:

(2-chloro-3-methoxyphenyl)boronic acid pinacol ester; 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione; With sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; at 45 ℃; for 2h;

With acetic acid; In tetrahydrofuran; water; for 0.25h;

With N-Acetylcysteine; In ethanol; water; at 75 ℃; for 2h;

upstream raw materials:

2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

dimethyl sulfate

Downstream raw materials:

5-(2-chloro-3-methoxy-phenyl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

4-chloro-6-(2-chloro-3-methoxyphenyl)-2-methylpyrimidine

3-[1-({6-[2-chloro-3-(methyloxy)phenyl]-2-methylpyrimidin-4-yl}amino)ethyl]benzenesulfonamide

Refernces